Technische Universität München, Germany
Although the existence of circular RNAs (circRNAs) has been known for over a decade, it was not until recently that the scientific community became aware of how widespread this phenomenon is. In fact recent reports, based on high-throughput sequencing of ribosome-depleted RNA, suggest that hundreds of circRNAs are expressed in mammalian cells. It has also been reported that due to their structure circRNAs show increased stability compared to linear RNA, which makes them interesting candidates for biomarker studies.
This talk will give an overview on the current state of knowledge about circRNAs, their detection in RNA-seq data and methods of experimental validation of specific candidates. In addition preliminary findings on circRNA-expression in the heart will be presented.
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