In silico functional analysis of microRNA: Towards the characterisation of miRNAs as biomarkers

Artemis Hatzigeorgiou 1,
1University of Thessaly, Greece 

RNA revolution has turned non-coding RNAs (ncRNAs) from dark-matter into a biological research hotspot. ncRNA families, such as microRNAs (miRNAs) and more recently, long non cod- ing RNAs (lncRNAs) are being researched for physiological and pathological implications. The role of miRNAs in development and diseasehas been widely reported during the past few years.
During the talk tools from the DIANA suite of miRNA analysis ( will be presented that can be used as basic step for the identification of miRNA biomarkers.
Such tools and databases include miRNA target prediction (DIANA micro-T) and annotation (TarBase, LNCBase), pathway analy- sis (DIANA–mirPath), regulation of microRNAs (miRGEN) and the use of RNAseq data for the identification of key regulatory components (miRNA and/or Transcription factors) based on two investigated stages (DIANA- mirExTra). The DIANA suite is widely used with more than 100,000 unique users per year from all over the world.

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